Folic acid, also known as vitamin B9, plays a key role in DNA synthesis, RNA transcription, homocysteine to methionine and cellular metabolism. Embryonic development is regulated by both environmental and genetic factors. Folic acid isan important nutrient for the normal development of animal embryonic organs. Maternal folic acid supplementation can reducethe risk of congenital organ dysplasia, such as heart, eyes, neural tube and kidney development abnormalities. In this study, weelucidates the involvement of folic acid transport, folic acid metabolism and the relationship between folic acid supplementationand epigenetic modifications in early embryonic organ development. In addition, we analyzed the effect of folic acid deficiencyon the development of animal embryonic organs and the importance of folic acid supplementation during pregnancy, providing atheoretical basis for the prevention and treatment of abnormal embryonic organ development in the future.