In this study, four typical metal-organic frameworks (MOFs), (MIL-101 (Cr), ZIF-8, UiO-66, and UiO-66-NH₂) were irradiated using electron beam radiation under different atmospheres (air, nitrogen), and dispersion liquids (water, methanol, and ethanol). The chemical composition, crystal structure, and surface morphology of MOFs before and after irradiation were characterized by Fourier transform infrared spectroscopy, X-ray diffraction spectroscopy, and scanning electron microscopy. The results showed that the corresponding infrared characteristic peaks, diffraction peaks, and surface morphology characteristics of all four MOFs did not change significantly after irradiation at the dose of 5 000 kGy, showing good radiation stability. This provides the basis for further application of MOFs in a radiation environment.