Real-time physiological information monitoring can predict and prevent disease, or improve treatment by early diagnosis. A comprehensive and continuous monitoring of human health requires highly integrated wearable and comfortable sensing devices. To address this need, we propose a low-cost electronic fabric-enabled multifunctional flexible sensing integration platform that includes a flexible pressure sensor for monitoring postural pressure, a humidity sensor for monitoring the humidity of the skin surface, and a flexible temperature sensor for visualizing the ambient temperature around the human body. Thanks to the unique rough surface texture, hierarchical structure, and robust electromechanical features of the MXene-modified nonwoven fabrics, the flexible pressure sensor can achieve a monitoring sensitivity of 1529.1 kPa⁻¹ and a pressure range of 150 kPa, which meets the demand for human pressure detection. In addition, the unique porous structure of the fabric and the stacked multilayer structure of MXene enable the humidity sensor to exhibit extremely high monitoring sensitivity, even through clothing, and still be able to detect the humidity on the skin surface. Temperature sensors based on screen-printed thermochromic liquid crystals enable visual monitoring in the range of 0 °C–65 °C. Through further integration with flexible printed circuit board circuits, we demonstrate a proof-of-concept device that enables real-time monitoring of human physiological information such as physical pressure, humidity, and ambient temperature environment, suggesting that the device provides an excellent platform for the development of commercially viable wearable healthcare monitors.