To reduce the high costs of mirror polishing and opto-mechanical assembly, and to correct low-order aberrations caused by thermal and gravity deformation, the so called “warping harness” has been used to apply moment to the pivot of whiffletrees to achieve real-time correction of the mirror surface. Indeed, warping harnesses have been adopted in some large astronomical telescopes. This study aimed to optimize the layout of actuators that may be applied to large optical telescopes in China in the near future. Firstly, the correction ability of the warping harness was determined according to engineering experience and the wider literature. Secondly, integrated modeling of the segment support assembly was carried out using 3D drawing software. Finally, the layout of actuators was optimized using finite element simulation and the least-squares method. The results show that an optimized design of 18 actuators can correct aberration of focus, astigmatism, coma, and trefoil. The design of 18 actuators not only meets the requirements of optical design, but also has a lower cost and higher efficiency.