In order to facilitate the setting up and reproduction of gearbox faults, a gearbox fault simulation device with a secondary drive has been designed and a signal acquisition and processing system has been developed based on LabVIEW software. The fault simulation system can simulate straight or helical tooth meshing faults and coupled gear and bearing faults at different speeds and ratios. The results show that the fault simulation experimental system is capable of measuring, acquiring and processing vibration signals, which can be used as a practical teaching and research platform for the fault diagnosis technology.