AbstractIn this article, the analysis of Tsallis holographic dark energy (which turns into holographic dark energy for a particular choice of positive non-additivity parameter δ) in modified f (T, B) gravity with the validity of thermodynamics and energy conditions for a homogeneous and isotropic FLRW Universe has been studied. The enlightenment of the field equation towards f(T,B)=&agr;Tm+βBn, made possible by the fact that the model is purely accelerating, corresponds to q = −0.54 (Mamon and Das 2017 Eur. Phys. J. C 77 49). The generalized second law of thermodynamics is valid not only for the same temperature inside the horizon, but also for the apparent horizon for a change in temperature. The essential inspiration driving this article is to exhibit the applicability that the holographic dark energy achieved from standard Tsallis holographic dark energy and the components acquired from f(T, B) gravity are identical for the specific bounty of constants. The analysis of energy conditions confirms that the weak energy condition and the null energy condition are fulfilled throughout the expansion, while violation of the strong energy condition validates the accelerated expansion of the Universe. With the expansion, the model becomes a quintessence dominated model. The dominant energy condition is not observed initially when the model is filled with genuine baryonic matter, whereas it appears when the model is in the quintessence dominated era.