The deformation of opto-mechanical system caused by environmental load should have a serious influence on the performance of the airborne camera. In order to evaluate this influence, an effective technique for intergrated opto-mechnical analysis is required. The finite element model of the airborne camera is established and the static analysis is accomplished. Under the given environmental loads, including heading acceleration, spanwise acceleration and normal acceleration, simulation and analysis are carried out on the deformation of the structure of airborne camera, especially on the deformation of the lens caused by environmental loads and the support structure. Zernike polynomial is used as an interface tool to fit deformed mirror surface and Zernike coefficients are substituted into optical design software for the intergrated optomechanical analysis. The influence of the given environmental loads on optical performance is evaluated. The analysis results show that under the given environmental loads the modulation transfer functions (MTF) of airborne camera′ s optical system in all fields of views are not less than 0.16 with spatial frequency from 0 to 62.5 cycle/mm, which can meet the image quality demand under the given environmental loads.