The error caused by aerosol is simulated when ozone is detected with three wavelength dual difference absorption lidar (D-DIAL) and two werelength difference absorption lidar (DIAL). The effects of the aerosol parameters on ozone detection are analyzed, including wavelength exponent and aerosol content. The impact of the factor C, which is introduced by the elimination to the scattering and extinction errors, on the detection results is discussed by using the three wavelength dual differential method. It shows that C optimal values make the error close to zero, and the optimal value of C is simulated. Different wavelengths are used respectively to simulate the error in multi wavelength difference absorption lidar on ozone detection. In the troposphere, the wavelengths of 266 nm and 308 nm (in DIAL), and 266, 289, 308 nm(in D-DIAL) are used, and in the stratosphere, the wavelengths of 308 nm and 351 nm, and 308, 339, 351 nm are used. The simulated results show that when aerosol scattering ratio R is 2, the error of D-DIAL method is less than 1%, and the error of DIAL method is 10%~45%. In the same aerosol content, the error of stratospheric ozone is significantly less than the error of tropospheric ozone. When the aerosol content is high, the error of D-DIAL detecting tropospheric ozone can reach 6%, and in the stratosphere the maximum error is only 3.5%.