Tuff is a kind of volcanic ash clastic rock which is scattered on the ground through volcanic eruption and solidified through compaction and hydration cementation, and it has certain pozzolanic activity. In this paper, the effect of curing temperature on the mechanical properties of tuff-based cementitious materials was studied, and the microstructure of hydration products of tuff-based cementitious materials was analyzed by means of FTIR, TG, SEM and MIP. The results show that the increase of curing temperature has a certain promotion and enhancement effect on the mechanical properties of tuff-based cementitious materials, which can not only improve the early strength, but also improve the later strength. The optimal curing temperature of tuff-based cementitious materials is 50 ℃. With the increase of curing temperature, no new hydration products are formed in the tuff-based cementitious material, but the content of hydration products such as AFt and C-S-H increases, and the content of Ca(OH)2 decreases. The increase of curing temperature is beneficial to increase the proportion of gel pores and transition pores in the tuff-based cementitious material, refine the pore size structure, reduce the porosity, and improve the density of matrix structure.