The high acidity and low hydration activity of fluorgypsum restrict its application in the field of plastering gypsum. In order to solve this problem and promote the large-scale application of fluorgypsum in plastering gypsum, CaO and Ca(OH)₂ were selected as neutralizer while Na₂C₂O₄, Na₂SO₄, K₂SO₄, K₂SiO₃ and gypsum hemihydrate were selected as activator, to modify fluorgypsum. The effects of type and dosage of activator and neutralizer on modification effect were investigated. The results show that 3%(mass fraction) neutralizer can improve the pH value of fluorgypsum to around 9 and keep its free fluorine content around 0.02% (mass fraction). Considering the cost, the cheaper CaO is choose as neutralizer. In addition, K₂SO₄, Na₂SO₄ and gypsum hemihydrate as activator have good excitation effect, among which Na₂SO₄ has the best excitation effect. Plastering gypsum excited by 1.0% (mass fraction) Na₂SO₄ is prepared, with initial setting time of 119 min and final setting time of 252 min. Moreover, the compressive strength is 10.30 MPa while the flexural strength is 3.85 MPa. It should be noted that all indicators reach the requirements of “Plastering gypsum”(GB/T 28627—2023).