In order to explore the influence of laser parameters on the cladding quality of 316L stainless steel powder on the 304# stainless steel plate and find out the optimal cladding parameters, a series of laser cladding experiments are carried out with a self-designed and assembled fiber laser cladding system. The surface morphology and cross sectional quality with different combinations of process parameters (laser power, cladding speed, laser frequency, defocusing amount, and so on) are detected and analyzed by means of laser scanning confocal microscope and Vickers hardness tester. The influence law of process parameters on the cladding quality is found and the optimum range of the cladding parameters is determined. The experimental results in this range show that the cladding surface is smooth with holonomic coating lines and without pores and cracks.