• Laser & Optoelectronics Progress
  • Vol. 61, Issue 18, 1800002 (2024)
Di Wang1, Ting Zhang1, Shanshan Liang2,*, and Jun Zhang1,**
Author Affiliations
  • 1School of Life and Environmental Science, Guilin University of Electronic Science and Technology, Guilin 541004, Guangxi, China
  • 2National Innovation Center for Advanced Medical Devices, Shenzhen 518083, Guangdong, China
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    DOI: 10.3788/LOP240603 Cite this Article Set citation alerts
    Di Wang, Ting Zhang, Shanshan Liang, Jun Zhang. Principle and Clinical Quantitative Analysis of Optical Coherence Tomography Angiography[J]. Laser & Optoelectronics Progress, 2024, 61(18): 1800002 Copy Citation Text show less

    Abstract

    Optical coherence tomography angiography (OCTA), derived from optical coherence tomography (OCT) technology, is a vascular imaging approach that leverages flowing red blood cells as an intrinsic contrast agent. It has key advantages, including high resolution, sensitivity, and noninvasiveness. By discerning the amplitude and phase variances within OCT signals between flowing red blood cells and stationary tissue, OCTA enables 3D imaging of the retinal vascular network. Leveraging vascular density, diameter, perimeter, and complexity indices, OCTA is a screening tool for ocular pathologies such as diabetic retinopathy (DR) and venous occlusion (VO), exhibiting notable efficacy in clinical interventions. This article provides an overview of the evolution of OCTA, elucidates its algorithmic fundamentals, delineates clinical quantitative metrics, and briefly evaluates the comparison between various OCTA methods and standard quantitative indicators.
    Di Wang, Ting Zhang, Shanshan Liang, Jun Zhang. Principle and Clinical Quantitative Analysis of Optical Coherence Tomography Angiography[J]. Laser & Optoelectronics Progress, 2024, 61(18): 1800002
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