High-quality insulator region proposals play important roles in the process of transmission line inspection images. A generation method of insulator region proposals based on edge boxes is proposed in this paper, and edge boxes are applied to the localization of insulators in inspection images creatively. We take a series of operations to generate insulator region proposals: K-means cluster is used on curvature scale space (CSS) points extracted from edge images, the most appropriate cluster number is chosen, and the circle is drawn on the insulator subclass. We consider the characteristics of insulators’ edge images, and combine these characteristics with edge boxes. As a result, more insulator region proposals are displayed. The experimental results show that our method can effectively reduce the interference area, meanwhile, has high quality of region proposals with fast calculation speed.