To solve the problems of slow convergence, ghosting and scene degradation in non-uniformity correction methods, a non-uniformity correction method based on trilateral filter and gradient weighted average filter was introduced．Firstly, trilateral filter was used to decompose the image into basic component and detailed component. Then, in order to decompose the scene details and the non-uniformity of detailed component, image sequence of detail components were filtered by weighted average filter. Finally, the corrected result could be obtained through subtracting non-uniformity from the original image. The experimental results show that the method can significantly suppress the ghosting and the scene degradation. The results of correction are superior to the THPF-NUC and NN-NUC in the aspects of subjective visual and objective evaluation index.