Femtosecond laser with central wavelength of 1 028 nm, repetition rate of 50 kHz and pulse width of 220 fs is used to write double line and tubular depressed cladding waveguides in Nd3+ doped photo-thermo-refractive glass. The influences of laser power, double line separation and diameters of tubular depressed cladding waveguide on the near-field modes of waveguides are investigated, and the waveguides with better guiding mode are obtained. Refractive index profile is reconstructed by intensity distribution of the near-field mode, the largest positive refractive index change for these two types of waveguides is +7.0×10-4 and +5.5×10-4, respectively. By using the scattering technique, the propagation loss of double line waveguide is about 1.29 dB/cm. The loss of tubular depressed cladding waveguide is less than 1.95 dB/cm by testing the insert loss. Therefore, waveguides inscribed directly by femtosecond laser in Nd3+ doped photo-thermo-refractive glass are promising candidates for the development of integrated optical device.