To meet the requirements of high precision, low delay and zero phase shift for detector analog signal acquisition, a field programmable gate array (FPGA)-based analogue digital (AD) signal acquisition adaptive system is designed. Incorporating with engineering application, the timing diagram and design flow chart of AD signal acquisition are given. The control of AD9653 chip is realized by FPGA logic based on the Zynq-7000 series devices from XILINX Company. FPGA logic is used to realize the control of AD9653 chip, which can ensure that analog signal on each channel, the digital signal after AD conversion to the entire pathway of FPGA are not vary with the difference of the printed circuit board (PCB) layout and wiring. The signal on each channel can adapt after passing to the Select IO hardware logic resources in FPGA and ensure the accuracy of data acquisition.