Sulfate radical-based advanced oxidation processes (SR-AOPs) are a highly promising technology for water treatment,and their processing capacity is affected by the catalyst. However, the existing catalysts are mostly powder-based and cannot meet the requirements of recovery and mass transfer in practical applications. Catalytic filtration membrane is a functional membrane that combines catalysis and filtration. It provides a support for the catalyst to ensure its recovery, and restricts the reaction to pores, facilitating a close contact between pollutants and active sites, thereby achieving efficient utilization of peroxymonosulfate. Sepiolite is an excellent catalyst carrier because of its excellent thermal stability, great adsorption capacity, and abundant acid-base sites. In addition, sepiolite is a high-quality film-making material with fibers interwoven into a mesh structure in the same or different directions. In the paper, we prepared a CuO/sepiolite catalytic filtration membrane (CuO/sepiolite) with excellent catalytic performance via impregnation-filtering coating-drying-calcination. In addition, the performance and activation mechanism of catalyzing peroxymonosulfate method were also investigated.