For small-scale image locating in a large image, an accurate locating method combining deep convolution network with SURF registering was introduced. The large-scale image was divided into several small reference images, and the feature of such reference image set was extracted to form a feature library by combining the deep convolution network and Similar Local Sensitive Hashing (SLSH); on the basis of the feature library, a two-stage method that carrying out accurate SURF registering after retrieval of multiple similar reference images was put forward to achieve the locating of small target in a large image. Experiment was established on high density FPC and location data of accurate final guidance image,and the results indicate that the method avoids approximately 90% in the amount of feature extraction by comparing with traditional SURF locating methods, in which registering is directly carried out in accordance with image features.So the method can ensure the locating precision, meantime can lower the time consumption by more than one order of magnitudes.