In consideration of the serious coupling and distributions in the attitude control of a reusable booster with a high angle of attack, a new kind of gain-scheduled attitude control strategy was presented. Firstly, each of the pitch, yaw and roll channels was treated separately by ignoring the intentional coupling among the channels, and the linear control model of each channel was established in a way different from that considering small perturbation linearization. Then, the gain-scheduled controller for each channel was designed, and the theory of coordinated gain scheduled control strategy was put forward based on the single gain-scheduled controller. Finally, the coordinated scheduled controller was designed to deal with the intentional cross coupling among different channels. The results of nonlinear real-time simulation validate that the tracking error of the attack angle has reduced about 2°, and the control accuracy of sideslip angle has improved about 0.4° by proposed strategy. The control system can satisfy the control performance requirement of the reusable booster, and the strategy of controller design is characterized by its clear physical concepts and easy engineering applications.