In order to improve the static power consumption and dynamic performance of piezoelectric ceramic drive power supply, a high-voltage amplifier with variable static operating point and operating voltage is proposed. First, an amplifier with a constant current source structure is used to construct a typical high-voltage amplifier. Then, the working current of the amplifier is dynamically adjusted by a proportional differential circuit. Finally, the multiple sets of tap power are used to supply power to the high-voltage amplifier in sections to further reduce system power consumption. The experimental results show that the amplifier can dynamically output 400 mA at 10 mA quiescent current; the working voltage of the amplifier can be automatically switched among 50 V, 100 V, 150 V, and 210 V according to the output voltage. The amplifier can obtain excellent dynamic characteristics at a very low quiescent current, which can meet the design requirements.