On the basis of the inverse Monte Carlo algorithm, a low coherent interferomtric measuring method for the glucose concentration was proposed, and the correlation of the glucose concentration and optical parameters was explored theoretically. The feasibility of reconstruction of absorption and scattering coefficients simultaniously according to interferometric curves was analyzed with the Monte Carlo method. By taking fat suspension Intralipid as a turbid sample, the effect of glucose concentration change on the interferometric signals of depth correlation was researched. Then the scattering and absorption coefficients of the sample were extracted separately and the solution glucose concentration was obtained by the variation from scattering and absorption coefficients indirectly. Results of low coherent measurement was proved by a double integral sphere system and the invariable systematic errors was corrected. With proper correction, it shows that the maximum relative errors are 2.52% and 3.11% for scattering and absorption coefficients respectively. The results demonstrate the strong correlation between glucose and interferomic line as well as scattering coefficient and prove that the scattering and absorption coefficients can be measured in a non-forward scattering.