From the point view of handheld/portable scenario, a dual optical fiber path is adopted as Raman optical probe structure, and the performances, types and sizes of key components are determined. Optical simulation is carried out by Zemax software. The working focal length of the incident light path is 13.5 mm, the image square numerical aperture is 0.23, meanwhile the image plane focal length of the collected light path is 13.46 mm and the numerical aperture is 0.235. The whole optical path and relative structures of the probe are simulated by SolidWorks software and TracePro software. Finally, the probe shell with overall dimensions of 50 mm × 33.5 mm × 17 mm is fabricated by computer numerical control and 3D printing, respectively. The Raman spectrum of alcohol detected by the designed probe are almost the same as that by commonly used products on markets, and has better signal performance in the wave number range from 200 cm－1 to 300 cm－1. The Raman spectrum of drugs with methamphetamine components and K powder tested by the designed probe are in accordance with the theoretical data. The experimental results have proved the practicability of the designed handheld/portable probe.