We demonstrate the dynamic coloration of polymerized cholesteric liquid crystal (PCLC) networks templated by the “wash-out/refill” method in the presence of organic compounds. The reflection colors were modulated by two key approaches, that is, the injection of mutually soluble organic fluids into a microfluidic channel and the diffusion of volatile organic compounds (VOCs). The reversible tuning of reflected colors with central wavelengths between $\sim 450\mathrm{nm}$ and $\sim 600\mathrm{nm}$ was achieved by alternative injection of nematic liquid crystal E7 (n_av = 1.64) and benzyl alcohol (n = 1.54) using syringe pumps. The fascinating iridescence with reflection centers from $\sim 620\mathrm{nm}$ to $\sim 410\mathrm{nm}$ was presented from the volatilization and diffusion of alcohol as a model VOC. Additionally, the flow velocity of fluid and the diffusion time were adjusted to explore the underlying mechanism for the dynamic coloration of cholesteric networks. This work is expected to extend the study of PCLCs as a dynamically tunable optofluidic reflector, visually readable sensor, or compact anti-counterfeit label in response to organic compounds.