A novel piezoelectric microspray dispensing system was designed based on a compliant mechanism. The system consisted of a glue supply device, driving device, and pin-impact valve. The motion characteristic of the dispensing system was that the elastic deformation of the compliant mechanism drived the colliding needle to move in a straight line to and fro, so that the opening and closing of the colliding needle valve could perform the function of microspray dispensing. The driving force, output displacement, and frequency characteristics of the dispensing system were obtained by using a pseudo-rigid-body method. The results show that the maximum of driving force, output displacement, and frequency of the system are 56.4 N, 808 μm, and 245 Hz, respectively. Thus, the driving force, stroke, and dispensing speed of the dispensing system can be guaranteed. The prototype was built and the effects of duty cycle, amplitude, frequency of driving voltage signal, and viscosity of glue on the droplet diameter were analyzed experimentally; the conditions for the formation of normal droplets were also determined. The experimental results show that the highest dispensing frequency of the system is 210 Hz, the minimum diameter of the droplets is 630 μm, and the consistency error of the droplets is 5.62 %. In a word, the advantages of the proposed dispensing system are verified, which provides a new concept for the design and application of microspray dispensing system.