The infrared imaging windows of the hyper/supersonic optical dome are encountering severe aero-optical effects (AOEs), so a flow control device, the ramp vortex generator array (RVGA) is proposed based on the ramp vortex generator to inhibit the supersonic mixing layers’ AOE, which is done by the nanotracer-based planar laser scattering technique and ray-tracing method. The experiments prove that under different pressure conditions, RVGA can reduce the mean and standard deviation of the root mean square of the optical path difference (${\mathrm{OPD}}_{\mathrm{rms}}$) and reduce the supersonic mixing layers’ thickness and mixture a great deal. The AOE of the pressure-matched mixing layer is the weakest. Higher RVGA results in better optical performance. RVGA has the potential to be applied to supersonic film cooling to reduce aero-optical aberrations.