The atomic oxygen perpendicular distribution of the middle and upper atmosphere (100～500 km) is simulated quickly and effectively based on the hydrostatics and mathematics software. The simulation results are compared with the data from MSISE-90 model, and they are coincident in order with certain difference in values. Results indicate that the method can simulate the atomic oxygen perpendicular distribution in 100～500 km range on each region and any time of the earth. The influence of actual atmosphere to this model is discussed fully including photochemistry reaction, diffusion, ionization, gravity wave, et al. Other component interactions go to dynamic balance finally except the gravity wave. Vertical distribution of temperature is stable comparatively, which is the result of the balance.