The off-axis laser disturbance on the camera is mainly caused by the laser diffraction and laser speckle interference. The models of the laser diffraction and the laser speckle interference are built respectively. The image of laser diffraction and laser speckle on the camera are analyzed under different parameters conditions, including the angle of incidence of laser beam, the caliber of lens, and the focal length of lens and F number. The effects of disturbing the camera by the laser diffraction and laser speckle interference are analyzed and compared at different parameters. The laser diffraction effect on the camera is significant when the laser beams are vertical incident to the space camera. The laser speckle interference effect becomes the leading role when the laser beams are oblique incident to the space camera.