• NUCLEAR TECHNIQUES
  • Vol. 48, Issue 1, 010403 (2025)
Yuanhao LIU, Liuxia LI*, Yi LIU, Zihuang PENG..., Yifan GAO and Fuchang LIN|Show fewer author(s)
Author Affiliations
  • State Key Laboratory of Advanced Electromagnetic Technology, School of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074, China
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    DOI: 10.11889/j.0253-3219.2025.hjs.48.240176 Cite this Article
    Yuanhao LIU, Liuxia LI, Yi LIU, Zihuang PENG, Yifan GAO, Fuchang LIN. Development of distributed arbitrary waveform high voltage pulse generator for controllable electroporation[J]. NUCLEAR TECHNIQUES, 2025, 48(1): 010403 Copy Citation Text show less
    Structural diagram of arbitrary high-voltage pulse power supply (a) Centralized structure, (b) Distributed structure
    Fig. 1. Structural diagram of arbitrary high-voltage pulse power supply (a) Centralized structure, (b) Distributed structure
    Diagram of the main circuit topology
    Fig. 2. Diagram of the main circuit topology
    Schematic diagram of drive system
    Fig. 3. Schematic diagram of drive system
    Schematic diagram of waveform modulation diagram
    Fig. 4. Schematic diagram of waveform modulation diagram
    Electric shock cup and its electric field distribution
    Fig. 5. Electric shock cup and its electric field distribution
    Simulation circuit of power generator
    Fig. 6. Simulation circuit of power generator
    Switch time sequences and output diagram of negative polarity sine wave
    Fig. 7. Switch time sequences and output diagram of negative polarity sine wave
    Simulation waveform of power output
    Fig. 8. Simulation waveform of power output
    Physical photo of a single pulsed power module
    Fig. 9. Physical photo of a single pulsed power module
    Physical photo of test platform
    Fig. 10. Physical photo of test platform
    Test waveforms of prototype (color online) (a) Simulation waveform, (b) Variable rising trapezoidal wave, (c) Bipolar exponential wave, (d) Gaussian wave
    Fig. 11. Test waveforms of prototype (color online) (a) Simulation waveform, (b) Variable rising trapezoidal wave, (c) Bipolar exponential wave, (d) Gaussian wave
    PI staining results (color online) (a) Positive square wave, (b) Exponential decay wave
    Fig. 12. PI staining results (color online) (a) Positive square wave, (b) Exponential decay wave

    工作模式

    Operation modes

    充电模式

    Charging mode

    正极性放电模式

    Positive discharge mode

    负极性放电模式

    Negative discharge mode

    旁路模式

    Bypass mode

    切尾模式

    Chopping mode

    通路示意Path scheme
    开关状态On-off stateOn: T, Sc and SdOff: Sa and SbOn: Sb and ScOff: T, Sa and SdOn: Sa and SdOff: T, Sb and ScOn: ScOff: T, Sa, Sb and SdOn: Sc and SdOff: T, Sa and Sb
    电压OutputUc-Uc0
    Table 1. Operation modes
    参数名称 Parameter符号Symbol数值Value
    极板间距 Distance / mml4
    极板高度 Altitude / mmh20
    极板宽度 Width / mmd10
    溶液电导率[24] Electric conductivity / mS·m-1σ8~80
    溶液相对介电常数[24] Relative dielectric constantεr89.99
    Table 2. Load parameters

    参数名称

    Parameter

    符号

    Symbol

    数值

    Value

    充电电压

    Charging voltage / V

    U500

    模块数量

    Number of modules

    M2

    模块内基本单元级数

    Number of basic units

    N8

    开关导通电阻

    Switch on resistance / mΩ

    Ron80

    每级储能电容

    Capacitance / μF

    C4
    负载电阻 Resistance / kΩR0.25~2.5
    Table 3. Main simulation parameters of generator

    最大幅值

    Max amplitude / kV·cm-1

    能量

    Energy / J

    电穿孔率

    Electroporation efficiency / %

    正极性方波Positive square wave21.20.4265.25±7.36
    指数衰减波Exponential decay wave21.00.4146.15±4.41
    Table 4. The experimental data of electroporation
    Yuanhao LIU, Liuxia LI, Yi LIU, Zihuang PENG, Yifan GAO, Fuchang LIN. Development of distributed arbitrary waveform high voltage pulse generator for controllable electroporation[J]. NUCLEAR TECHNIQUES, 2025, 48(1): 010403
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