A temperature and glucose solution concentration sensor based on intrinsic evanescent wave was proposed and fabricated. By studying on the relationship between the thickness of etched fiber coating and the output spectrum, the suitable etching thickness was determined. The cladding of a standard single-mode optical fiber was etched to 2.4 μm, and the temperature and glucose solution concentration sensing were realized by measuring the variation of output optical power, because optical fiber evanescent wave is extremely sensitive to the change of external medium. The experimental results show that the sensor has temperature sensitivity of 9.58×10－3 dBm/°C at the range of 10~70 °C with linearity as high as 99.36% and glucose solution concentration sensitivity of 0.126 dBm/(g/L) at the concentration range of 0~3% with linearity of 97.95%. The response time of the sensor is less than 30 s. The sensor has advantages of simple operation, high accuracy, good reproducibility and wide application range, thus has potential application value.