In considering the exciting ability of driving Distributed-feedback quantum cascade laser in infrared carbon monoxide detection, a novel generator under experimental validation was carried out accordingly. Firstly, low ripple power supply and perfect protective module were developed, which improved the quality of drive pulse significantly and ensured the reliability of the power supply work. Secondly, corresponding function circuits were designed by the concept of “Multiple Isolation”. So the system anti-interference ability was enhanced greatly. Lastly, deep voltage feedback method and proportional-integral-differential control theory were used to improve the stability of drive current efficiently. Utilizing illustrated driver, driving test was conducted on one Distributed-feedback quantum cascade laser with center wavelength at 4.76 μm, which was fabricated by institute of semiconductor, CAS. Experimental results demonstrate during a long-term operation (200 h), stability of drive current is 2.5×10-5, linearity of the drive power system is 0.04%, which meet the requirements of driving Distributed-feedback quantum cascade lasers and provide a strong guarantee for infrared carbon monoxide detection.