The recycling of reclaimed polyurethane concrete (RPC) has not been explored yet. Therefore, this paper proposes an indoor simulation preparation method of RPC. Polyurethane recycled mixture (PRM) with 7 kinds of RPC content was prepared with polyurethane as binder. The bonding properties of polyurethane and RPC interface and the influence of RPC content on the road performance and durability of PRM were studied, and the prediction model of PRM road performance and durability with RPC content was established. The results show that RPC meets the relevant technical requirements of the specification for aggregates. The los angeles wear loss, soft stone content, sand equivalent and angularity are higher than those of limestone, and the crushing value and apparent density are lower than those of limestone. The bonding performance of the interface between polyurethane and RPC is superior; with the increase of RPC content, the road performance and durability of PRM show a downward trend. Under the same RPC content, splitting strength of PRM gradually decreases and tends to be stable with the increase of freeze-thaw cycles and aging time. With the increase of RPC content, the splitting strength of PRM decreases more significantly with the increase of freeze-thaw cycles and aging time.