In this paper, corrosion resistance experiment on fused-cast refractory materials was performed to study the cast refractory materials. The erosion behaviors of soda-lime glass, high aluminum glass and lithium aluminum glass on fused-cast refractory materials were studied by chemical analysis, lithofacies analysis and electron microscopy spectroscopy analysis. The results show that the alkali metal ions in the molten glass diffuse to the glass phase of the refractory, which leads to the viscosity of the glass phase decrease. At the same time, the corundum phase dissolves and the inclined zircon disperses, then the main structure of the refractory is destroyed, and the interfacial layer is formed. There is a glass phase rich in aluminum and zirconium in the interface layer. Due to the high alumina content and high surface tension of high aluminum glass and lithium aluminum glass, the glass phase in the interface layer gathers around the sample and diffuses slowly, thus preventing the development of erosion. The erosion rate of the molten glass is: soda-lime glass>high aluminum glass>lithium aluminum glass.