In this paper, a localized surface plasmon resonance (LSPR) refractive index sensor based on photonic crystal fiber (PCF) is proposed to solve the problem of low refractive index analyte detection. 31 silver nanowires are placed on the surface of the D-shaped PCF, which increases the contact area between the plasma material and the analyte. The simulation results indicate that the maximum sensitivity of the sensor reaches 16 400 nm/RIU, and the refractive index detection range is 1.26—1.33. It is proved that the sensor has a good prospect in low refractive index detection.