Comparison study of photoacoustic and ultrasound spectrum analysis in osteoporosis detection

Weizhen He; Yunhao Zhu; Ting Feng; Jie Yuan; Qian Cheng; Guan Xu; Xueding Wang

doi:10.3788/COL201715.111101

Journals >Chinese Optics Letters >Volume 15 >Issue 11 >Page 111101 > Article

Chinese Optics Letters
Vol. 15, Issue 11, 111101 (2017)

Comparison study of photoacoustic and ultrasound spectrum analysis in osteoporosis detection

Weizhen He¹, Yunhao Zhu¹, Ting Feng², Jie Yuan^1,*..., Qian Cheng³, Guan Xu⁴ and Xueding Wang^3,4|Show fewer author(s)

Author Affiliations

¹School of Electronic Science and Engineering, Nanjing University, Nanjing 210046, China

²School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China

³Department of Physics, Tongji University, Shanghai 200092, China

⁴Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA

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DOI: 10.3788/COL201715.111101 Cite this Article Set citation alerts

Weizhen He, Yunhao Zhu, Ting Feng, Jie Yuan, Qian Cheng, Guan Xu, Xueding Wang, "Comparison study of photoacoustic and ultrasound spectrum analysis in osteoporosis detection," Chin. Opt. Lett. 15, 111101 (2017) Copy Citation Text

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Abstract

Osteoporosis is a progressive bone disease, which is characterized by a decrease in the bone mass and deterioration in bone micro-architecture. In theory, photoacoustic (PA) analysis has the potential to obtain the characteristics of the bone effectively. In this study, we try to compare the PA spectral analysis (PASA) method with the quantitative ultrasound (QUS) method in osteoporosis assessment. We compare the quantified parameter slope from the PASA and broadband ultrasound attenuation from QUS among different bone models, respectively. Both the simulation and ex vivo experiment results show that bone with lower bone mineral density has the higher slope in the PASA method. Our comparison study proves that the PASA method has the same efficiency as QUS in osteoporosis assessment.