To investigate the road performance and mechanical properties of polyurethane mixture with dense skeleton structure, the design theory of multi-gravel asphalt concrete was used to design the composition of polyurethane concrete. A variety of performance tests were carried out to evaluate the road performance of multi-gravel polyurethane concrete, and the mechanical properties were evaluated based on uniaxial penetration test, uniaxial compressive test and uniaxial tensile test. The results show that the dynamic stability of multi-gravel polyurethane concrete is 53.4 times and 17.8 times that of matrix asphalt mixture and asphalt mastic gravel mixture. The maximum bending strain at low temperature is 2.26 times and 1.95 times respectively, and the fatigue life is 26.0 times and 12.7 times， respectively. In terms of mechanical properties, temperature has little effect on the uniaxial penetration strength and penetration amount of multi-gravel polyurethane concrete. The compressive and tensile elastic modulus of multi-gravel polyurethane concrete are much smaller than that of cement concrete, but larger than that of asphalt mastic gravel concrete. Multi-gravel polyurethane concrete has excellent road performance. Temperature has little effect on the shear mechanical properties of multi-gravel polyurethane concrete. The multi-uniaxial tensile and compressive mechanical properties are between asphalt mixture and cement concrete, which can be applied to pavement structure paving.