The main aerodynamic forces and component aerodynamic forces of a typical design point without and with jets are calculated with the computational fluid dynamics （CFD） methods，aiming at the attitude-orbit control interference problem of the nozzle and grid fin layout.The longitudinal and lateral aerodynamic forces of different combinations of circumferential positions of grid fins and jet directions are compared.The results show that under longitudinal jets，the interference of the pitching moment mainly generated by the missile body is significant whether the layout is ×-× or ×-+；while under lateral jets，the interference of the rolling moment mainly generated by the force asymmetry of the grid fins is significant when the layout is ×-+ but little when the layout is ×-×.Therefore，the comprehensive interference performance of the ×-× layout is superior to that of the ×-+ layout.