In order to extend the measurement of the nonlinear effect intensity to the fifth-order nonlinear, the fifth-order nonlinear effect in the electromagnetically induced transparency system is studied theoretically. The research results show that the quantum coherence effect greatly enhances the nonlinear effects of electromagnetically induced transparency system, including susceptibility of third-order nonlinear which can simulate Raman scattering and four-wave mixing, fifth-order nonlinear susceptibility with two completely different nonlinear absorption and dispersion.The fifth-order cross nonlinearity of the nonlinear absorption excites the four-photon absorption and the fifth-order cross nonlinearity of the nonlinear gain excites the super Raman scattering. The fifth-order cross nonlinearity of the electric polarization of the nonlinear absorption excites the six-wave mixing.