Multispectral remote sense camera can obtain geometic and spectral properties of the surface scenery, and will be wildly used in optical remote sense fields, but the blue spectrum of multispectral camera is more prone to out-band response. The paper established a mathematical model of multispectral remote sense camera′s spectral response, analyzed the reason of the blue band out-band response, and proposed blue spectrum out-band response correction method according to each spectral response relationship of multispectral remote sense camera used Time-Dealy-Integration Charge-Coupled-Device. Through statistics of typical objects obtain the correction formula of correction blue spectrum out-band response, the corrected residuals can be smaller than 4%, can meet the application requirement of multispectral remote sense camera. The correction results show that the correction method based on each spectral response has better applicability in correcting the blue spectrum out-band response.