Under the macro background of improving the system of ecological civilization, to promote the modernization of national governance system and governance capacity, the paper systematically combs the origin, implementation characteristics, effectiveness and shortcomings of land use regulation system, focuses on analyses of the reform logic of the transformation from land use regulation to territorial space use regulation and its specific requirements for territorial spatial planning, so as to provide reference for improving the territorial spatial planning system. The results show that: (1) The land use regulation system emphasizes the protection of cultivated land, and establishes a complete control chain of land use classification - land use planning - land use plan - approval and supervision with the newly added construction land as the main control object. The land use regulation system has achieved good results in protecting cultivated land, ensuring food security, forcing the conservation and intensive use of land and improving the awareness of using land in accordance with laws and regulations. But there are still some deficiencies, such as incomplete coverage, too rigid regulation, and weak regulation of ecological land. (2) The construction of ecological civilization is the logical starting point of territorial space use regulation. And territorial space use regulation is transforming from single land type protection to space overall planning, from land use type regulation to space management and control, from index transmission to the combination of index and zoning, from bottom line restriction to both constraint and guidance, to build a whole process and diversified regulatory rule system and improve the spatial transmission mechanism of territorial space use regulation, and then realize the unified control of all elements of territorial space. (3) In the face of the needs of the era of territorial space use regulation, the reform of territorial spatial planning should make positive responses in the aspects of systematic and integrated control index system, zoning system covering the whole region and linking up the upper and lower planning, flexible mechanism of planning implementation combining bottom line constraint and incentive guidance, and "whole chain" management mechanism, and then realize the coordinated management and control of different levels of territorial spatial planning and territorial space use regulation.