This study derives the analytical expressions for the propagation factor and spatial expansion of radially polarized partially coherent twisted beams (RPPCTBs) in anisotropic atmospheric turbulence, with a focus on the effects of beam parameters, such as twisting factors and atmospheric turbulence parameters including anisotropic factors, on beam propagation characteristics. Using numerical simulation calculations, the effects of the initial coherence length, beam waist width, wavelength, twist factor, anisotropy factor, turbulence inner scale, turbulence outer scale, and generalized exponential parameters on the beam transmission quality are analyzed. Simulation results show that by decreasing the initial coherence length of the beam and increasing the beam waist width and wavelength, the transmission quality of the beam can be improved. Moreover, the twisting factor of the beam is increased and the beam shows a small transmission factor, demonstrating that the beam can be adjusted reasonably and the twisting phase can effectively improve the antiturbulence ability of the beam.