In this study, time resolved (TR) Monte Carlo (MC) simulation program code was run to generate photon fluencies with increasing time steps. TR MC simulation was performed for ten time series from 4 ps to 52 ps. Generated photon fluencies were transferred to the image analysis programming platform. Imaging device geometry was created for test purpose in image reconstruction programming platform environment. Forward model weight matrix functions were calculated during each time period for 38 sources, and 38 detectors according to the back-reflected imaging geometry. A homogenous phantom, which simulated tissue, was chosen. Depending on the homogeneous tissue optical properties, such as tissue absorption coefficient μa, and tissue scattering coefficient μs, photons emitted from the laser source positions; migrated differently inside the imaging tissue. Photons migrate inside the tissue by some multiplication factor of ps depending on the tissue type for each 100-micrometer vertical distance. Superficial photons come photodetector point fast, depend on the source-detector neighborhood distances and tissue optical properties, respectively. Time resolved diffuse optic tomography (TRDOT) imaging systems are an emerging biomedical optic imaging modality due to progressive electronic technologies are helping to build the systems faster and cheap. As such, emerging microelectronic technology is giving important access to design and implement compact laser sources and photodetector units. Vertical cavity surface emitting light (VCSEL) as laser source and single photon avalanche diode (SPAD) arrays as photodetector units are becoming in common use as important hardware tools for designers and researchers in this field. TR diffuse photon analysis should be done routinely for better understanding of TRDOT devices. Hence, MC simulation driven TR photon fluence analysis was done for such a purpose in this study.