The fatigue effect of actuators of deformable mirrors would be generated under the longterm action of the alternating electric field in the process of the wavefront correction in adaptive optics systems. According to the error and openloop transfer functions of adaptive optics control systems and the fatigue characteristics of piezoelectric ceramic actuators, the influence of the fatigue of piezoelectric ceramic actuators on the delay time, correction bandwidth of deformable mirrors and system stability was discussed. The results show that the properties of piezoelectric, dielectric and electromechanical coupling of piezoelectric ceramic all decrease with the increasing of cycle times, in which the electromechanical coupling properties have the greatest influence on the delay time of the deformable mirrors. In the process of correcting the distortion wavefront by the deformable mirrors, both the error rejection bandwidth and the openloop bandwidth decrease with the increasing of the cycle of the piezoelectric ceramic actuators and the delay time of the deformable mirrors. Meanwhile, the variation range of phase margin increases gradually, resulting in the worsening of the stability of the system.