In this paper, the effects of three types of commonly used adhesives were studied via experiment and simulation. The results show that the strain sensitivity of fiber Bragg grating (FBG) sensor is about 1.201 pm/με and the effects of three adhesives of epoxy resin, AB glue and 502 glue with the same thickness and length on sensitivity coefficients of FBG sensors are 99.20%, 93.80% and 96.50%, respectively. Finally, the sensitivity coefficient of the simulated FBG sensor is the same as the test result by ANSYS modeling.