Contents
2024
Volume: 51 Issue 21
25 Article(s)

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Biomedical Optical Imaging
Research Progress and Prospects of Low‑Power Stimulated Emission Depletion Microscopy
Haoxian Zhou, Luwei Wang, Renlong Zhang, Fangrui Lin, Liwei Liu, and Junle Qu
SignificanceKnown for its non-invasive and non-destructive nature, optical microscopy can provide structural and functional insights into biological specimens, thus driving progress in fields such as biology, medicine, and related disciplines. Over the past four centuries, optical microscopy has witnessed significant d
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107101 (2024)
Application of Segment Anything Model in Medical Image Segmentation
Tong Wu, Haoji Hu, Yang Feng, Qiong Luo, Dong Xu, Weizeng Zheng, Neng Jin, Chen Yang, and Jincao Yao
SignificanceThe application of deep neural networks to image segmentation is one of the most prevalent topics in medical imaging. As an initial step in computer-aided detection processes, medical image segmentation aims to identify contours or regions of interest within images, thereby providing valuable assistance to
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107102 (2024)
Advancement in Structured Illumination Microscopy Based on Deep Learning
Xinran Li, Jiajie Chen, Meiting Wang, Xiaomin Zheng, Peng Du, Yili Zhong, Xiaoqi Dai, Junle Qu, and Yonghong Shao
SignificanceStructured illumination microscopy (SIM) is a pivotal technique in super-resolution microscopy as it offers an innovative approach to enhance the spatial resolution exceedingly beyond that achievable by conventional optical microscopes. SIM harnesses the principle of structured illumination, where finely pa
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107103 (2024)
Comprehensive Review of Acceleration Techniques for Monte Carlo Simulations of Photon Transport in Biological Tissues
Louzhe Xu, and Ting Li
SignificanceIn the dynamic field of biomedical photonics, simulating light transport in biological tissues has become a cornerstone for advancing medical diagnostics, therapeutic interventions, and understanding photobiological processes. This research area is crucial due to its potential to transform a wide range of b
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107104 (2024)
Fluorescence Fluctuation‐Based Super‐Resolution Microscopic Imaging Based on a Multilayer Perceptron
Zhiping Zeng, Biqing Xu, Jin Qiu, Xinyi Chen, Canhua Xu, and Yantang Huang
ObjectiveDue to its economic advantages, convenience of use, and wide applicability, fluorescence fluctuation-based super-resolution microscopy has rapidly advanced in recent years and has garnered increased attention and application. Compared with other super-resolution imaging techniques, fluorescence fluctuation-bas
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107105 (2024)
Huber Iterative Hard Threshold Algorithm in an Application Study of Fluorescence Molecular Tomography
Yating Yuan, Huangjian Yi, and Xiaowei He
ObjectiveFluorescence molecular tomography (FMT), which can observe the three-dimensional distribution of fluorescent probes in small animals via reconstruction algorithms, has become a promising imaging technology for preclinical studies. The strong scattering property of biological tissues and limited boundary measur
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107106 (2024)
Diabetic Retinopathy Lesion Segmentation Based on Hierarchical Feature Progressive Fusion in Retinal Fundus Images
Pengchao Ding, and Feng Li
ObjectiveDiabetic retinopathy (DR) is one of the most common complications of diabetes and one of the main causes of irreversible vision impairment or permanent blindness among the working-age population. Early detection has been shown to slow the disease's progression and prevent vision loss. Fundus photography is
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107107 (2024)
Fundus Microvascular Image Segmentation Method Based on Parallel U‐Net Model
Xinjuan Liu, Xu Han, and Erxi Fang
ObjectiveThe fundus is the only part of the human body where arteries, veins, and capillaries can be directly observed. Information on the vascular structure of the retina plays an important role in the diagnosis of fundus diseases and exhibits a close relationship with systemic vascular diseases such as diabetes, hype
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107108 (2024)
Large‑Deformation 3D Medical Image Registration Based on Multi‑Scale Constraints
Yu Shen, Ziyi Wei, Yuan Yan, Shan Bai, Yangyang Li, Bohao Li, Baoqu Gao, Zhenkai Qiang, and Jiarong Yan
ObjectiveMedical image registration is a spatial transformation process that aligns and matches the specific spatial structures contained in two medical images. It has been applied in disease detection, surgical diagnosis and treatment, and other fields. Traditional medical image registration methods are slow and compu
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107109 (2024)
Full‐Automatic Brain Tumor Segmentation Based on Multimodal Feature Recombination and Scale Cross Attention Mechanism
Hengyi Tian, Yu Wang, and Hongbing Xiao
ObjectiveBrain tumors pose a significant threat to human health, and fully automatic magnetic resonance imaging (MRI) segmentation of brain tumors and their subregions is fundamental to their computer-aided clinical diagnosis. During brain MRI segmentation using deep learning networks, tumors occupy a small volume of m
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107110 (2024)
Bio-Optical Sensing and Manipulation
Recent Advances and Applications of Surface‐Enhanced Raman Spectroscopy Technology Based on Flexible Substrates
Nan Wang, Yi Liu, Jun Zhang, Shaohua He, Shihong Hou, Shangyuan Feng, and Duo Lin
SignificanceSurface-enhanced Raman spectroscopy (SERS) is an optical sensing technology based on local surface plasmon resonance, which greatly enhances the Raman signal of molecules adsorbed or very close to the surface of rough nano-metals, even achieving single-molecule detection. The traditional SERS substrate is c
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107401 (2024)
Holography and Information Processing
Frequency Decomposition and Double-Branch Feature Extraction for Multispectral-Image-Compression Network
Dexiao Xu, Fanqiang Kong, Kun Wang, Xu Fang, and Murong Huang
ObjectiveMultispectral images, as captured using aerospace optical instruments, feature high spectral resolutions and abundant information. Hence, they are used extensively in the military, meteorology, mapping, and other fields. However, their large memory size poses significant transmission and storage challenges to
Chinese Journal of Lasers
  • Publication Date: Oct. 29, 2024
  • Vol. 51, Issue 21, 2109001 (2024)
Wide Field‐of‐View Multiscale Noncontact Photoacoustic Intelligent Defect‐Detection Algorithm
Jijing Chen, Yihan Pi, Yixuan Pang, Hao Zhang, Kaixuan Ding, Ying Long, Jiao Li, and Zhen Tian
ObjectiveDuring the fabrication of flip chips, challenges to production yield and longevity arise owing to preparation defects, including delamination, missing solder bumps, and cracks. These defects typically manifest at dimensions ranging from the submillimeter to micron scale and are characterized by pronounced rand
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2109002 (2024)
Laser Devices and Laser Physics
Design Analysis and Experimental Study on Target‑Alignment System of Multibeam Picosecond PW Laser
Haitao Kang, Ping Zhu, Dongjun Zhang, Xiuyu Yao, Youjian Yi, Zhaoliang Li, Miaoyan Tong, Neng Hua, Zhanfeng Qiao, Mingying Sun, Jianxing Li, and Jianqiang Zhu
ObjectiveInertial confinement fusion (ICF) is the primary approach for achieving controlled nuclear fusion. To enhance the efficiency of laser fusion energy and attain higher yields, Tabak proposed a fast-ignition scheme for ICF. A critical challenge in fast-ignition fusion schemes is precisely guiding multiple high-en
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2101001 (2024)
Actively Q‑switched Fiber Laser with Smooth Pulse Based on Coupler Ring
Dong Zhang, Qiao Lu, and Wencai Li
ObjectiveUtilizing actively Q-switched fiber lasers to generate high-energy narrow-linewidth nanosecond laser pulses is a mainstream technology. Various types of active Q-switches have been developed based on different principles. Among them, fiber-pigtailed acousto-optic modulators (AOMs) and electro-optic modulators
Chinese Journal of Lasers
  • Publication Date: Nov. 05, 2024
  • Vol. 51, Issue 21, 2101002 (2024)
Measurement and Metrology
Distributed Cavity Phase Shift Analysis of Atomic Clocks Based on Intracavity Cooling
Siminda Deng, Wei Ren, Jingfeng Xiang, and Desheng Lü
ObjectiveThe development of laser-cooling technology has advanced cold-atomic-frequency standards, thus enhancing the precision of defining a second to 10-16. Additionally, the second definition with a frequency uncertainty of 10-19, which offers even greater accuracy, is anticipated to be established in the optical-fr
Chinese Journal of Lasers
  • Publication Date: Nov. 05, 2024
  • Vol. 51, Issue 21, 2104001 (2024)
Neurophotonics and Optical Regulation
All‑Optical Physiology for Neural‑Circuitry Analysis
Cheng Jin, and Lingjie Kong
SignificanceThe “brain program”, which focuses strategically on neuroscience research, has been launched worldwide. The construction of neural connection maps is the basis of neuroscience research. Meanwhile, the analysis of neural circuits can provide a basis for investigations into the mechanisms of perception, memor
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107301 (2024)
Manipulating Conformational Dynamics of BODIPY to Improve Fluorescence Lifetime Imaging
Lin Jiang, Xiaofei Miao, Zizi Wu, Mingxuan Jia, Quli Fan, and Wenbo Hu
ObjectiveFluorescence lifetime imaging (FLIM) technology utilizes photoluminescence lifetime instead of intensity as a detection signal to effectively avoid autofluorescence interference from tissues, thereby providing enhanced imaging accuracy and comprehensive information regarding biochemical and cellular environmen
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107302 (2024)
Investigation of Cerebral Blood Flow Correlation and Asynchrony Using Transcranial Doppler Ultrasound and Diffuse Correlation Spectroscopy
Junqi Wang, Wangwei Sun, Shuning Xu, Xusheng Wu, and Yu Shang
ObjectiveThe stable supply of cerebral blood flow (CBF) is crucial for maintaining the normal physiological function of the brain. This regulation relies on complex physiological mechanisms involving the collaboration between the basilar arteries and the microvascular network that penetrates the brain parenchyma. Altho
Chinese Journal of Lasers
  • Publication Date: Nov. 04, 2024
  • Vol. 51, Issue 21, 2107303 (2024)
Optical Diagnostics and Therapy
Microscale Applications of Optical Ultrasound
Lin Li, Fan Wu, Lei Wang, Li Wang, and Pu Wang
SignificanceUltrasound has been widely used in various clinical fields as a safe, low-cost, portable, and fast imaging technology. Currently, piezoelectric transducers are the primary means of generating ultrasound. However, the limited bandwidth of the ultrasound signals generated by the piezoelectric effect restricts
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107201 (2024)
Development of Magnetic‑Induction Hyperthermia System
Jianfeng Zhang, Wangbo Jiao, Haiming Fan, and Xiaoli Liu
SignificanceMagnetic-induction hyperthermia, also known as magnetic hyperthermia, is an emerging physical-therapy modality for treating tumors clinically. It utilizes magnetic nanomaterials to generate heat under an alternating magnetic field (AMF), thereby triggering molecular events that selectively destroy tumor cel
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107202 (2024)
Mueller-Matrix Characterization of Sclerosing Adenosis and Invasive Ductal Carcinoma Tissues
Jinkui Chu, Xiaohan Ding, Yongtai Chen, Bo Huang, Bing Jiang, and Benda Xin
ObjectiveStudies show that breast cancer ranks first among all cancers affecting women in China. Additionally, its mortality rate is high and continues to increase. The five-year relative survival rate of patients with breast cancer who are detected at an early stage is ? 90%, whereas it is only 20% for those detected
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107203 (2024)
Construction of Near‑Infrared Laser‑Responsive Composite Hydrogel and Its Antibacterial Study
Shiran Gou, Jiaru Xian, Boqi Pang, Mengting Li, and Ping Yang
ObjectiveThis study investigates a novel photothermal composite hydrogel (PGS-Cu/PTCP) derived from cuttlebone β-tricalcium phosphate, which is responsive to near-infrared (NIR) laser for oral photothermal therapy (PTT). This study can potentially contribute to enhancements in the safety and efficacy of bone-defect rec
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2107204 (2024)
Rapid Communications
[in Chinese]
Peng Wang, Mingye Yang, Hanshuo Wu, Yun Ye, Baolai Yang, Xiaoming Xi, Hanwei Zhang, Xiaolin Wang, Fengjie Xi, Zefeng Wang, Xiaojun Xu, Pu Zhou, and Jinbao Chen
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2116001 (2024)
[in Chinese]
Xiulu Hao, Shanmin Huang, Min Fu, Chenchen Fan, Liyang , Chenzilun , Lengjinyong , Yaotianfu , Yaotianfu , Leibing , and Zhoupu
Chinese Journal of Lasers
  • Publication Date: Oct. 31, 2024
  • Vol. 51, Issue 21, 2116002 (2024)
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