Pressure-sensitive paint technology is a wind tunnel pressure measurement frontier technology with high economical efficiency and high speed. In the wind tunnel test, due to the strong wind, the model will be distorted, making the wind image and the windless image difficult to register, which will seriously affect the pressure mea-surement accuracy. In response to this problem, this paper innovatively applies the two-dimensional non-rigid iterative closest point (ICP) algorithm to solve this problem. The point cloud method is used to make the image detail area to be effectively registered, and it is also conducive to the subsequent three-dimensional reconstruction work. However, due to the two-dimensional non-rigid ICP algorithm, only the two-dimensional coordinate positional rela-tionship is considered. The correlation of the pixel grayscales of the pressure-sensitive paint image is neglected, so that the registration accuracy is not too high. However, if the three-dimensional non-rigid ICP algorithm is directly used, misregistration will occur. Therefore, in order to further improve the registration accuracy, this paper proposes a non-rigid ICP algorithm based on pixel-based search strategy. The algorithm designs a dual-target search strategy that takes 2D coordinates and pixel gray values into consideration and achieves accurate local matching, realizing point search and double goal optimization. The algorithm of this paper is compared with five registration algorithms on multiple sets of pressure sensitive paint images. The experimental results show that the proposed algorithm has the best registration accuracy. Compared to the suboptimal algorithm, the RMSE is improved by more than 15% and the NMI is increased by about 5%.