Estimation of Metformin Drug for the Diabetes Patients by Simple, Quick and Cheap Techniques within the Formation of Colored Charge Transfer Complexes

Omar B. Ibrahim; El-Sayed A. Manaaa; M.M. AL-Majthoub; Ahmed M. Fallatah; Abdel Majid A. Adam; Mha M. Alatibi; Jehan Y. Al-Humaidi; Moamen S. Refat

doi:10.3964/j.issn.1000-0593(2018)11-3622-09

Journals >Spectroscopy and Spectral Analysis >Volume 38 >Issue 11 >Page 3622 > Article

Spectroscopy and Spectral Analysis
Vol. 38, Issue 11, 3622 (2018)

Estimation of Metformin Drug for the Diabetes Patients by Simple, Quick and Cheap Techniques within the Formation of Colored Charge Transfer Complexes

Omar B. Ibrahim^1,*, El-Sayed A. Manaaa^2,3, M.M. AL-Majthoub¹, Ahmed M. Fallatah¹..., Abdel Majid A. Adam¹, Mha M. Alatibi¹, Jehan Y. Al-Humaidi⁴ and Moamen S. Refat^1,5|Show fewer author(s)

Author Affiliations

¹Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, Zip Code 21974, Taif, Saudi Arabia

²Department of Chemistry, Faculty of Applied Medical Science, Taif University, KSA

³Nuclear Materials Authority, El-Maadi, Egypt

⁴Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, KSA

⁵Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt

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DOI: 10.3964/j.issn.1000-0593(2018)11-3622-09 Cite this Article

Omar B. Ibrahim, El-Sayed A. Manaaa, M.M. AL-Majthoub, Ahmed M. Fallatah, Abdel Majid A. Adam, Mha M. Alatibi, Jehan Y. Al-Humaidi, Moamen S. Refat. Estimation of Metformin Drug for the Diabetes Patients by Simple, Quick and Cheap Techniques within the Formation of Colored Charge Transfer Complexes[J]. Spectroscopy and Spectral Analysis, 2018, 38(11): 3622 Copy Citation Text

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Abstract

Metformin (Met) is a drug developed for the treatment of patients with type Ⅱ diabetes. Recently, Met estimation in pharmaceutical formulations and human fluids has gained a growing interest. To extend requisite data that can be used to assessment of Met quantitatively based on charge-transfer (CT) complexation, the present study describes the synthesis and characterization of CT complexes that formed between drug Met and the organic π-acceptors picric acid (PA), chloranilic acid (CLA), chloranil (CHL), 7,7’,8,8’-tetracyanoquinodimethane (TCNQ), and dichlorodicyanobenzoquinone (DDQ). The properties of the formed CT complexes were investigated by elemental, spectral (UV-visible, IR, and Raman spectroscopies), thermal (TG) and morphological (SEM) studies. IR results indicated that the complexation of Met with either PA or CLA acceptors occurs through proton transfer interaction, whereas its complexation with CHL, TCNQ, or DDQ acceptors occurs through n→π* interaction.

Keywords

Acceptor Anti-diabetic drug Charge-transfer complex Metformin Solution study

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