The distribution characteristics of hydrogen flow in local single space is a special concern of nuclear power plant and hydrogen storage device. In this paper, a single compartment of the experimental device is used as a geometric structure to establish a computational fluid dynamics analysis model for the numerical study of hydrogen distribution in small-scale space. By comparing the experimental data with the simulated data, the choice of the optimal turbulence model is given, and the flow distribution of hydrogen in small-scale space under low mass flow rate condition is simulated. The numerical simulation results obtained by Realizable k-ε, RNG k-ε and Standard k-ε turbulence models in the six two-equation turbulence models agree well with the experimental data, which can accurately reflect the release process and distribution of hydrogen in small-scale space. In low mass flow rate case, the radial range of the mainstream region of hydrogen is small, and hydrogen is stably and evenly distributed in the middle and upper part of the compartment.