Maintenance of aircraft skin with partially faded paint requires multipaint layer laser removal controllability. Based on the response surface analysis method, a mathematical model between laser parameters (spot lap rate, laser power, and number of scans) and the key indicators of controllable paint layer removal (paint layer removal thickness and surface roughness) is established, and the influence of laser multiparameter coupling on key indicators is analyzed. The results show that the influence of laser parameters on paint layer removal thickness is in the order of number of scans,laser power, and spot lap rate, wherein all are positively correlated. Meanwhile, surface roughness decreases with an increase in spot lap rate, increases with an increase in laser power, and has a peak effect with number of scans. Therefore, the response surface model provides a reference for laser controllable paint removal with the thickness accuracy of ±5 μm, providing method guidance and theoretical support for laser controllable aircraft skin paint layer removal.