Multiple evaluation of the effect of 60Co-γ irradiation sterilization on the quality of Fructus forsythiae

Tengxiao MAO; Xinran WU; Congcong ZHANG; Long CHENG; Jiaojiao ZHENG; Qi DAI; Jiang HE

doi:10.11889/j.1000-3436.2024-0049

Journals >Journal of Radiation Research and Radiation Processing >Volume 43 >Issue 1 >Page 010403 > Article

Journal of Radiation Research and Radiation Processing
Vol. 43, Issue 1, 010403 (2025)

Multiple evaluation of the effect of ⁶⁰Co-γ irradiation sterilization on the quality of Fructus forsythiae

Tengxiao MAO¹, Xinran WU¹, Congcong ZHANG¹, Long CHENG¹..., Jiaojiao ZHENG^1,*, Qi DAI¹ and Jiang HE²|Show fewer author(s)

Author Affiliations

¹Key Laboratory of Chemical Quality Research and Control, Chengdu Institute For Drug Control, Chengdu 610045, China

²Key laboratory of Irradiation Preservation Sichuan Province, Sichuan Institute of Atomic Energy, Chengdu 610101, China

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DOI: 10.11889/j.1000-3436.2024-0049 Cite this Article

Tengxiao MAO, Xinran WU, Congcong ZHANG, Long CHENG, Jiaojiao ZHENG, Qi DAI, Jiang HE. Multiple evaluation of the effect of ⁶⁰Co-γ irradiation sterilization on the quality of Fructus forsythiae[J]. Journal of Radiation Research and Radiation Processing, 2025, 43(1): 010403 Copy Citation Text

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HPLC fingerprint chromatograms of Fructus forsythiaeirradiated by different doses of 60Co-γ ray

Fig. 1. HPLC fingerprint chromatograms of Fructus forsythiaeirradiated by different doses of ⁶⁰Co-γ ray

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Antibacterial activity against Staphylococcus aureusof water extract of Fructus forsythiae: (a) the concentration of the extract shows a good linear relationship with the diameter of the inhibition zone; (b) there is no significant difference in the diameter of the inhibition zone before and after irradiation at concentrations of 0.26 g/mL and 0.33 g/mL (p > 0.05)

Fig. 2. Antibacterial activity against Staphylococcus aureusof water extract of Fructus forsythiae: (a) the concentration of the extract shows a good linear relationship with the diameter of the inhibition zone; (b) there is no significant difference in the diameter of the inhibition zone before and after irradiation at concentrations of 0.26 g/mL and 0.33 g/mL (p > 0.05)

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Fig. 3. Near-infrared spectrogram of Fructus forsythiaesamples (color online)

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Fig. 4. Near-infrared consistecy evaluation model of Fructus forsythiaesamples

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批数 Lot number	吸收剂量 / kGy Absorbed dose	连翘酯苷I / (mg·g^-1) Forsythiaside I	连翘酯苷A / (mg·g^-1) Forsythiaside A	连翘苷 / (mg·g^-1) Forsythin	连翘水提物（0.33 mg/L）抑菌圈直径 / mm Diameter of inhibition zone for water extract of Fructus forsythiae(0.33 mg/L)
1 2	0	7.35	36.75	3.60	15.07
	5	7.33	36.82	3.65	15.11
	10	6.52^**	34.48^**	3.63	14.99
	0	7.31	35.76	3.67	15.10
	5	7.33	36.25	3.64	15.06
	10	6.34^**	34.14^**	3.64	14.95

Table 1. Content of each constituent and the diameter of the inhibition zone for Staphylococcus aureus of the water extract of Fructus forsythiae before and after irradiation

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批数

Lot number

吸收剂量/ kGy Absorbed dose

1.000

0.999

0.923

1.000

0.999

0.936

Table 2. HPLC fingerprint chromatograms similarity of Fructus forsythiaeirradiated by different doses of ⁶⁰Co-γ ray

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批数 Lot number	吸收剂量 / kGy Absorbed dose	微生物限度检查 /（CFU·g^-1） Microbial limit testing
批数 Lot number	吸收剂量 / kGy Absorbed dose	TAMC	TYMC	BGNB
1	0	3.8×10⁷	1.6×10⁶	10²<N<10³
	5	1 500	340	<100
	10	<100	<100	<100
2	0	6.2×10⁶	8.5×10⁴	10²<N<10³
	5	5 400	250	<100
	10	<100	<100	<100

Table 3. Effects of different doses of ⁶⁰Co-γ irradiation on the microorganism of Fructus forsythiae

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