In order to investigate the effective distance and retrieval method of CCD laser beam imaging technique in detecting ozone concentration profile, a hardware detection system was designed. This system employed the 266 nm and 280 nm continuous-wave laser as differential absorption lidar transmitter. The signal-to-noise ratio (SNR) of detection echo signal was simulated based on the main parameters, such as laser power, exposure time, the effective area of CCD camera, aerosol concentration and ozone concentration. Supposed that aerosol is clean, pollutant and heavy pollutant types and ozone concentration is low and high cases, with the uncertainty of less than 10%, theoretical analysis results show that the effective detection distance is more than 2 km under the condition of three different aerosols cases with low ozone concentration; the effective detection distance is still more than 2 km under the clean and pollutant aerosol cases and more than 1.7 km under heavy pollutant aerosol with high ozone concentration; the retrieval ozone concentration profiles are consistent to the assumed ones. The simulation results are helpful to understand the optimal parameters of CCD laser beam imaging technique in detecting ozone concentration profile and then realize effective detection to ozone concentration profile.